Esomeprazole Is A Specific Inhibitor Of The Gastric Enzyme

By Author: Jack Alexander
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Nexium (Esomeprazole) magnesium (a substituted benzimidazole), reduces gastric acid secretion through a highly targeted mechanism of action. It is a specific inhibitor of the gastric enzyme H+, K+-ATPase (the proton pump) which is responsible for acid secretion by the parietal cells of the stomach.

Mechanism of action:

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion.

Indications:

Esomeprazole magnesium trihydrate tablets are indicated for treatment of circumstances where a reduction of gastric acid secretion is essential such as: reflux esophagitis, maintenance treatment of patients with reflux esophagitis, symptomatic gastroesophageal reflux disease (i.e. heartburn and regurgitation), and H. pylori eradication.

Side effects:

• dizziness, confusion;
...
... • fast or uneven heart rate;
• jerking muscle movements;
• jittery feeling;
• muscle cramps, muscle weakness or limp feeling;
• cough or choking feeling; or
• Seizure (convulsions).

Contraindications:

• It is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles
• Symptomatic response to therapy does not rule out the presence of gastric malignancy
• Atrophic gastritis has occasionally been noted with long-term therapy with omeprazole
• PPI therapy may be associated with increased risk of Clostridium difficile-associated diarrhea
• Avoid concomitant use of this product with clopidogrel, due to a reduction in plasma concentrations of the active metabolite of clopidogrel. When using this drug consider alternative anti-platelet therapy
• Long-term and multiple daily dose proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine
• Hypomagnesemia has been reported rarely with prolonged treatment with PPI therapy and may require discontinuing PPI therapy
• Concomitant use of this product and St. John’s wort or rifampin can substantially decrease NEXIUM concentrations. Avoid concomitant use

Precautions:

Esomeprazole may increase the risk for bone fractures, especially with longer use, higher doses, and in older adults. To prevent bone loss/fracture, by taking such as calcium (such as calcium citrate) and vitamin D supplements.
During pregnancy, this medication should be used only when clearly needed.

DOSING:

• For GERD, 20 or 40 mg of esomeprazole is given once daily for 4-8 weeks. In children ages 1-11, the dose is 10 or 20 mg daily.
• For the treatment of H. pylori, 40 mg is administered once daily in combination with amoxicillin and clarithromycin for 10 days.

Hi everyone, this is Jack Alexander from USA. I am completed P.HD in pharmacy. I do lots of work in pharmacy but now I am working in pillssupplier.com. I also write blog on all health related product like Kamagra, PrestiQ, paxil, calcium, zyven etc. For more please visit : http://pillssupplier.com/