Is Grape Seed Extract Antifungal

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Grape seed extract contains one of the most beneficial groups of plant flavonoids, proanthocyanidins, which exert many healing effects on the body. Meanwhile, it is an exceptional antioxidant and possesses anti bacterial, anti viral and anti-inflammatory properties. This may make it a Candida antifungal.

Potential Use
Grape Seed extract is an antioxidant and is also useful for killing candida. It does it indirectly by making your immune system stronger. You can’t find anything specific for candida except to help build the immune system, thus reducing the effects of candida. The only Candida that the medical community truly recognizes is that developed by many AIDS patients after they have diminished immune system response.

Chronic candidiasis can be successfully treated with grape seed extract according to the many clinics and medical practitioners now prescribing it. Dr Leo Galland, who prescribes it for chronic candidiasis, has reported treatment failure in less than 1% of cases, and considers it to be "a major therapeutic breakthrough for patients with chronic parasitic and yeast infections."

Significance ...
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For a long time, Amphotericin B (Amp B) is considered as a drug of choice for treatment of fungal infections, but it causes severe side effects such as renal damage. To lessen the severity, it is often combined with the azole, but data reporting resistance of Candida albicans to the azole have been recently increasing. Thus, finding a new product that can reduce Amp B dose by combination seems to be important. In the present study, scientists investigated a synergic effect of grape seed extract (GSE) combined with Amp B against the fungus. Their results showed that the grape seed extract alone can inhibit growth of Candida albicans cells. Upon combination of GSE plus Amp B, the combination therapy strikingly retarded the yeast growth as determined by the broth susceptibility method, according to the study.

Dose-dependent Action
The anti-fungal effects of grape seed extract are dose-dependent, meaning they are stronger at higher doses. The extract has more antimicrobial action than fungus-fighting ability, according to a 2011 "African Journal of Biotechnology" study. The antibacterial action also is dose-dependent. The extract's antimicrobial properties coupled with its generally recognized as safe status in terms of human consumption might make grape seed extract useful for controlling harmful bacteria, such as Listeria monocytogenes, on or in foods, according to a 2010 "Journal of Food Protection" study.

Side Effects

No health hazards or side effects are known with properly administered therapeutic dosages. A reversible inhibition of intestinal enzymes activity of alkaline phosphatase, sucrase, and dipeptidase has been observed in animal studies.

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