Cas No 144701-48-4 (telmisartan)

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Understanding Telmisartan: A Comprehensive Guide to CAS Number 144701-48-4
Telmisartan, with the Chemical Abstracts Service CAS number 144701-48-4, is a widely prescribed medication primarily used for managing high blood pressure (hypertension) and protecting the kidneys in patients with type 2 diabetes. It belongs to a class of drugs known as angiotensin II receptor antagonists (ARBs), which work by blocking the action of a hormone called angiotensin II. This hormone typically causes blood vessels to constrict, leading to increased blood pressure. By inhibiting this action, Telmisartan helps lower blood pressure and improves overall cardiovascular health.

Chemical Structure and Properties
Telmisartan is an organic compound with the molecular formula C20H18N4O3. Its structure consists of a benzimidazole ring system fused to a tetrazole ring, making it part of a broader group of sartans. This specific configuration allows Telmisartan to bind effectively to the angiotensin II type 1 receptor (AT1), which is responsible for the majority of the effects of angiotensin II on blood pressure regulation.
Some ...
... key properties of Telmisartan include:
Molecular weight: 514.39 g/mol
Solubility: Practically insoluble in water but soluble in organic solvents like methanol and dimethyl sulfoxide (DMSO).
Chemical Name: 4'-(2-(4-(2-(1H-tetrazol-5-yl)-phenyl)-thiazol-5-yl)-phenyl) thiazol-2-yl)-[1,1'-biphenyl]-4-carboxylic acid.
This structure contributes to its long half-life, which allows it to be taken once a day.
Mechanism of Action
Telmisartan works by blocking the action of angiotensin II, a potent vasoconstrictor that can elevate blood pressure. The drug specifically targets the angiotensin II type 1 receptor (AT1). By binding to this receptor, Telmisartan prevents angiotensin II from exerting its effects, which include narrowing blood vessels, increasing sodium reabsorption by the kidneys, and stimulating the release of aldosterone. The result is vasodilation (widening of blood vessels), reduced blood pressure, and decreased strain on the heart.
Benefits and Uses of Telmisartan
Telmisartan is primarily prescribed for the treatment of hypertension. However, it has several additional uses and benefits:
Hypertension (High Blood Pressure): Telmisartan helps to reduce high blood pressure, which lowers the risk of heart attack, stroke, and kidney problems. By relaxing blood vessels, it eases the workload on the heart and promotes better circulation.
Cardiovascular Protection: It has been shown to reduce the risk of heart attack and stroke in individuals with existing cardiovascular diseases, improving long-term outcomes for patients at risk.
Renal Protection in Diabetic Nephropathy: In patients with type 2 diabetes, Telmisartan can protect against kidney damage (nephropathy) by reducing proteinuria (the presence of excess protein in the urine) and slowing the progression of kidney disease.
Reduction in Risk of Cardiovascular Events: Studies suggest that Telmisartan can lower the risk of major cardiovascular events, especially in high-risk individuals, due to its beneficial effects on blood pressure and overall vascular health.
Dosage and Administration
Telmisartan is usually administered orally, in the form of tablets, and is typically available in 20 mg, 40 mg, and 80 mg dosages. The recommended starting dose for most individuals is 40 mg once a day. However, depending on the patient's condition, this dose may be increased to 80 mg per day.
It’s important for individuals on Telmisartan to follow their healthcare provider's instructions carefully, as dosage adjustments may be needed based on blood pressure readings or kidney function.
Side Effects and Precautions
Like any medication, Telmisartan can cause side effects, although not everyone will experience them. Common side effects include:
Dizziness or lightheadedness, especially when standing up quickly.
Headache and fatigue.
Elevated potassium levels (hyperkalemia), which can cause irregular heartbeats and muscle weakness.
Low blood pressure (hypotension), especially in those who are also taking other antihypertensive medications.
Serious but rare side effects can include:
Angioedema, a condition where swelling occurs in the face, lips, tongue, or throat, which can be life-threatening if it obstructs the airways.
Liver or kidney problems, particularly in patients with pre-existing kidney disease.
Patients should avoid taking Telmisartan if they are pregnant or planning to become pregnant, as it can cause harm to the developing fetus. It is also important for individuals with a history of renal artery stenosis or severe liver disease to inform their healthcare provider before starting treatment.
Drug Interactions
Telmisartan may interact with other medications, including:
Other antihypertensive drugs (e.g., diuretics, ACE inhibitors, or calcium channel blockers), which can enhance the blood-pressure-lowering effects and potentially cause low blood pressure.
Lithium, as the combination with Telmisartan can increase the risk of lithium toxicity.
Nonsteroidal anti-inflammatory drugs (NSAIDs), which may reduce the effectiveness of Telmisartan in lowering blood pressure and increase the risk of kidney damage.
Conclusion
Telmisartan (CAS No. 144701-48-4) is a highly effective medication for managing high blood pressure and providing protection against cardiovascular and renal complications. As an angiotensin II receptor antagonist, it offers long-lasting control of hypertension with a relatively favorable side-effect profile. However, like any medication, its use should be monitored by a healthcare provider, especially in patients with underlying conditions or those taking multiple medications.
If you or someone you know is considering Telmisartan for managing high blood pressure or other related conditions, it's essential to have a discussion with a healthcare provider to determine if this treatment is appropriate based on individual health needs.
URL: For more information, visit Verdant Pharma : CAS number 144701-48-4 Telmisartan