The X-linked Hypophosphatemia Market Is Driven By Increasing Disease Prevalence

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The X-linked Hypophosphatemia Market comprises drugs and therapies used for the treatment of X-linked hypophosphatemia, a rare inherited disorder characterized by phosphate concentration below the normal reference range, rickets, and osteomalacia. Some key therapies available in the market include phosphate supplements, calcitriol, recombinant human PTH 1-84 injection, and calcimimetics. These therapies help normalize serum phosphate levels, improve bone mineralization, and promote bone remodeling and healing of rickets and osteomalacia.
The X-linked Hypophosphatemia Market is estimated to be valued at US$ 1.5 Bn in 2024 and is expected to exhibit a CAGR of 9.4% over the forecast period 2024-2031.
Key players operating in the X-linked Hypophosphatemia are Ultragenyx Pharmaceutical, Kyowa Kirin, Ascendis Pharma, Pfizer, Chiesi Farmaceutici. Key players are focusing on expanding their product portfolios by developing new and advanced therapies. For instance, in 2020, Ascendis Pharma received FDA approval for its long-acting Investigational recombinant growth hormone therapy called SKYTROFA injection for the treatment ...
... of pediatric growth hormone deficiency.
The growing incidences of osteomalacia, rickets, and X-linked hypophosphatemia worldwide are expected to drive the market growth during the forecast period. According to the Ultragenyx Pharmaceutical, the estimated prevalence of XLH is 1 in 20,000 live births globally. Moreover, lack of awareness regarding the disease, delayed diagnosis, and lack of effective treatment options available in many countries are further fueling the patient pool.
The global expansion of key players through partnerships and collaborations is also anticipated to boost the market growth. For instance, in 2022, Kyowa Kirin entered into an exclusive distribution agreement with Chiesi Farmaceutici for Kyowa Kirin's treatment options for X-linked Hypophosphatemia across Europe.
The key factors driving the X-linked Hypophosphatemia Market include the increasing disease prevalence, new product launches, rising healthcare expenditure, growing awareness regarding early diagnosis and available treatment options. In addition, the supportive regulatory environment providing more approvals to innovative treatment regimens, increased focus of pharma players on orphan and rare disease drugs are offering various opportunities for market growth.
Market Drivers
The increasing prevalence of X-linked Hypophosphatemia globally acts as a major driver for the market. As per National Organization for Rare Disorders (NORD), the prevalence ranges from 1 in 20,000 individuals for males and 1 in 40,000 individuals for females. Moreover, increasing awareness regarding early diagnosis and available treatment options, including recombinant human PTH therapy and new pipeline drugs for XLH is also fueling the market growth.
Current Geopolitical Situation And Its Impact On X-Linked Hypophosphatemia Market Growth
The X-linked Hypophosphatemia Market is witnessing significant impacts of the prevailing geopolitical conditions across various regions. The ongoing conflict between Russia and Ukraine has disrupted international trade and logistics to some extent. Although the direct impact of this conflict on the market is limited, it has exacerbated global supply chain issues and economic uncertainties. Rising inflationary pressures and recessionary fears in major economies like the US and Europe are posing challenges for healthcare providers and consumers. This can slow down the adoption of new drugs and therapies in the short term. Additionally, currency fluctuations due to increased volatility in foreign exchange rates are affecting the pricing and profitability of pharmaceutical companies globally.
To ensure sustainable growth in such a dynamic and uncertain environment, companies operating in the XLH market need to focus on diversifying their manufacturing and distribution networks. Having manufacturing backups and alternatives across different geopolitical regions can help minimize supply disruptions. Further, investing in digital health solutions and patient assistance programs can enhance affordability and accessibility of XLH treatments. Partnerships with generic drugmakers and focus on emerging markets also provide opportunities for expanded revenue streams. Continuous monitoring of geopolitical, economic and trade policies will be critical to devise agile long-term strategies. Overall, a multipronged approach considering global as well as regional dynamics is important for stakeholders in this specialty pharmaceutical market.
Geographical Regions With High Market Concentration
The X-linked Hypophosphatemia Market witnesses high concentration of revenues in the major markets of North America and Europe. Collectively, these developed regions accounted for over 70% of the global market value in 2023. Among them, the US holds the top position with a share of around 40% last year. This can be attributed to presence of favorable reimbursement structures, larger patient population and higher spending ability of consumers in the country. Europe is the second largest regional market led by key markets like Germany, UK, France and Italy. The mature markets in these regions offer stable growth opportunities due to established awareness and diagnostic rates of XLH. However, with increasing accessibility of advanced healthcare in emerging nations, the market concentration patterns may gradually shift towards Asia Pacific and Rest of World regions over the coming years.
Fastest Growing Regional Market
The Asia Pacific region has emerged as the most lucrative and fastest growing market for XLH globally. It is estimated that the Asia Pacific X-linked Hypophosphatemia Market will expand at a CAGR of over 12% during 2024-2031. This impressive growth can be accredited to rising healthcare expenditures, growing middle-class population and improving access to specialty medications across major Asian countries. Rapid economic development and increasing diagnosis rates are also bolstering the market growth momentum. Among Asia Pacific nations, China and India hold the largest potential due to their huge patient pools and enhancing healthcare facilities. Other emerging countries like South Korea, Indonesia, Thailand and Malaysia will continue to offer new frontiers driven by expanding medical infrastructures and insurance coverage in the near future.
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What Are The Key Data Covered In This X-linked Hypophosphatemia Market Report?
:- Market CAGR throughout the predicted period
:- Comprehensive information on the aspects that will drive the X-linked Hypophosphatemia Market's growth between 2024 and 2031.
:- Accurate calculation of the size of the X-linked Hypophosphatemia Market and its contribution to the market, with emphasis on the parent market
:- Realistic forecasts of future trends and changes in consumer behaviour
:- X-linked Hypophosphatemia Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa
:- A complete examination of the market's competitive landscape, as well as extensive information on vendors
:- Detailed examination of the factors that will impede the expansion of X-linked Hypophosphatemia Market vendors
FAQ’s
Q.1 What are the main factors influencing the X-linked Hypophosphatemia Market?
Q.2 Which companies are the major sources in this industry?
Q.3 What are the market’s opportunities, risks, and general structure?
Q.4 Which of the top X-linked Hypophosphatemia Market companies compare in terms of sales, revenue, and prices?
Q.5 Which businesses serve as the X-linked Hypophosphatemia Market’s distributors, traders, and dealers?
Q.6 How are market types and applications and deals, revenue, and value explored?
Q.7 What does a business area’s assessment of agreements, income, and value implicate?
*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it