123ArticleOnline Logo
Welcome to 123ArticleOnline.com!
ALL >> Business >> View Article

Strong Bones May Be Vital For Maintaining Memory In Old Age

Profile Picture
By Author: Anton Bluman
Total Articles: 65
Comment this article
Facebook ShareTwitter ShareGoogle+ ShareTwitter Share

A hormone released by bones seems to reverse age-related memory loss. The hormone can be boosted by exercise, suggesting that lifting weights might protect the brain from the ravages of old age.

Eric Kandel of Columbia University in New York and colleagues were interested in understanding the mechanisms behind normal age-related memory loss.

To investigate, they measured mRNA levels associated with the expression of 23,000 genes in human brain tissue. Genes use mRNA to tell cells to make products such as proteins — mRNA levels therefore reflect how active a gene was before death.

The team focused their analysis on the dentate gyrus, a brain region particularly affected by memory loss as we grow older.

The brain tissue came from eight healthy people aged between 33 and 88. Across these people, one gene — called RbAp48 — became steadily less active with age. This gene is known to be involved in the process by which we turn short-term memories into long-term memories.

Health bones, healthy brain

Kandel’s team went on to show that a relationship exists between RbAp48 and osteocalcin, ...
... a hormone secreted by bone.

Osteocalcin has many functions, one of which seems to be involved in cognition — mice who carry a mutation that makes them deficient in the hormone have memory deficits. Replacing this hormone improves their memory.

Osteocalcin’s effects, however, appear to be dependent on the expression of RbAp48 in the dentate gyrus. When Kandel’s team silenced the gene in mice, they had memory deficits in spite of osteocalcin’s presence. Kandel’s team also discovered that mice deficient in osteocalcin have lower amounts of RbAp48 and that injections of the hormone increased the amount of the RbAp48 protein in the dentate gyrus.

Natural decline

The upshot of the research is that osteocalcin, produced by bones, and mediated by RbAp48, appears vital to a healthy memory. This is supported by the fact that age-related osteoporosis in which bones lose their strength and produce less osteocalcin — has been linked to memory loss.

Get More Info : https://mindcarecenter.net/strong-bones-may-be-vital-for-maintaining-memory-in-old-age/

Website : https://mindcarecenter.net/

Total Views: 72Word Count: 329See All articles From Author

Add Comment

Business Articles

1. How Global Trade Finance Facilitates Cross-border Transactions And Reduces Risk
Author: Riddhi Divan

2. Innovative Uses Of Nickel In Cryogenic And Marine Environments
Author: Online fittings

3. Implementing Predictive Analytics In Your Abm Toolkit
Author: SalesMark Global

4. Comparing The Top 5 Live Commerce Platforms For 2024
Author: Amy Williams

5. Data-driven Precision Marketing For Effective Demand Generation
Author: SalesMark Global

6. Supercharge Your Sales With Optimized Pipeline Velocity
Author: SalesMark Global

7. Best Japan Tour Packages
Author: bharathi

8. Adani Group Stocks Down 20%; Gautam Adani Indicted In Us Over Bribery Charges
Author: Bizzbuzz

9. High-performance Ss Round Bars: Addressing The Energy Sector's Needs
Author: Neelkamal Alloys LLP

10. The Role Of Modern Washroom Solutions In Maintaining Cleanliness
Author: ritika krishna

11. Why Choose Premium Taxi Services In Kochi?
Author: maya

12. Black Magic Astrologer In Kasaragod
Author: Sripandith05

13. The Health Benefits Of Adding Pineapple To Your Pancakes
Author: maya

14. Top Luxury Resorts In Kerala For Your Dream Vacation
Author: maya

15. How To Start Your Shopping Website In Doha: A Simple Guide
Author: maya

Login To Account
Login Email:
Password:
Forgot Password?
New User?
Sign Up Newsletter
Email Address: