Magnesium: The First Line Of Psychiatric Depression Defence - Pubrica

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World Health Report states that depression accounts for 40% of all neuropsychiatric disorders. Depression is a disease characterized by a lack of energy, mood swings, fluctuations in weight, interrupted sleep, waking up very early morning, gain or lossof appetite, etc. People with depression display an increased sensitivity to social challenges.They do not respond correctly at times and become eccentric. They get upset very easilyand feel guilty. Such candidates have a suicidal tendency. The typical symptoms of depression include difficulty with memory and concentration, apathy, fatigue, emotional lability, irritability, nervousness, anxiety, insomnia, migraine headaches, constipation, dysmenorrhea, fibromyalgia, autism and attention deficit hyperactivity disorder(Wang et al. 2018).

The role of magnesium in our body:

Magnesium plays a crucial role in medical regulating contraction of all kinds of muscles, blood pressure, metabolism of insulin, for an optimal transmission of the nerves, coordination of nerves and muscles, protection against excitotoxicity, synthesis of DNA, RNA and proteins. N-methyl-D-aspartate ...
... coupled calcium channels are opened when magnesium is deficient. Magnesium serves as a cofactor in several enzymatic reactions.Neurotransmitters, DNA metabolism and mood regulation depends largely on magnesium.In clinical care, the central nervous system has the maximum concentration of magnesium which accounts for brain balance. Glutamate is an excitatory neurotransmitter which is kept within limits by an appropriate magnesium level. GABA is yet another neurotransmitter kept under control with the binding of magnesium to GABA receptors.
. In such medical conditions, calcium and glutamate are take up by the neuron instead magnesium, which in turn leads to deregulation of synaptic function, finally leading to the condition of depression. Hippocampal kindling is suppressed and protein kinase C is modulated by magnesium ions. P-glyocprotein is also affected by lower levels of magnesium. P-glycoprotein maintains the permeability of blood-brain barrier to glucocorticoids. Affecting this protein causes an alteration in hypothalamic-pituitary-adrenal axis, which finally damages the hippocampus. Magnesium has an anti-inflammatory effect, which makes it an antidepressant of high potential(Kirkland, Sarlo, and Holton 2018).

The ways magnesium gets depleted:

Processed foods lack magnesium and their intake results in magnesium deficiency in our body. Black beans, pumpkin seeds, cashews, almonds and dark chocolate are some of the food items rich in magnesium.Intake of antacids, diuretics, caffeine and alcohol also decreases magnesium levels. Since human beings of the modern world tend to eat processed foods and such beverages, the levels of magnesium in their bodies are getting depleted and is becoming the main reason for major depression and other psychiatric disorders.

Effects of magnesium administration :

The positive side is that mood and cognition gets improved and better with the administration of magnesium such that the normal levels of magnesium gets restored in the body.People tend to show healthy eating patterns, good response to stress conditions, better quality of sleep, improvements in efficacy of modalities such as medications, etc. So it is very important for all of us to have a sufficient intake of food items enriched with magnesium so that the minimal body requirements of magnesium are met with. It is advised by doctors all over the world to avoid junk and polished foods which are devoid of crucial minerals. Minerals like magnesium are required in very small amounts in our body but play major roles in several metabolic pathways and a deficiency in this mineral will evidently result in depressive disorders in humans(Ryszewska-Pokraśniewicz et al. 2018).

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